Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies

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Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies
Please use this identifier to cite or link to this item: https://astaroar.ripplewerkz.co/communities-collections/articles/12141
Title:
Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies
Journal Title:
Cancer Research
DOI:
10.1158/0008-5472.CAN-13-3568
OA Status:
closed
Publication URL:
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.CAN-13-3568
Authors:
Y. Li, V. Tergaonkar
Keywords:
Publication Date:
05 March 2014
Citation:
Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies Yinghui Li and Vinay Tergaonkar Cancer Res March 15, 2014 74:1639-1644; Published OnlineFirst March 5, 2014; doi:10.1158/0008-5472.CAN-13-3568
Abstract:
Telomerase plays a pivotal role in bypassing cellular senescence and maintaining telomere homeostasis, essential properties required for the sustenance and progression of cancer. However, recent investigations have uncovered extratelomeric properties of telomerase that are independent of its role in telomere extension. This review summarizes recent insights to the noncanonical functions of telomerase reverse transcriptase (TERT) catalytic subunit, in particular in cancer progression, and highlights two major signaling mechanisms involved in the cross-talk with TERT—the NF-κB and Wnt/β-catenin pathways. We propose a feed-forward regulatory loop mechanism underlying TERT activation in cancers in which TERT acts as a transcriptional modulator of oncogenic signaling pathways that sustain its own levels and control the induction of target genes critical for tumor cell survival and proliferation. Finally, we provide a new perspective on telomerase-targeted cancer therapies and suggest possible interventions targeting the nontelomeric roles of TERT. This therapeutic strategy can be used in the future targeting of other telomerase components that exhibit novel nontelomeric functions in cancer and other ailments. Cancer Res; 74(6); 1639–44. ©2014 AACR.
License type:
PublisherCopyrights
Funding Info:
Description:
Full paper can be downloaded from the Publisher's URL provided.
URI:
https://astaroar.ripplewerkz.co/communities-collections/articles/12141
ISSN:
0008-5472
1538-7445
Collections:
Institute of Molecular and Cell Biology
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