Lin, L. H. A.; Lim, C. Y.; Gerken, H.; Wu, J. C.; Zhao, H., Furfural and hydroxymethylfurfural tolerance in Escherichia coli ΔacrR regulatory mutants. Biotechnology and Applied Biochemistry 2015, 62 (1), 32-36.
Abstract:
The presence of the highly toxic furfural and hydroxymethylfurfural (HMF) in the hydrolysate of lignocellulosic biomass prompted the investigation of the Escherichia coli ΔacrR regulatory mutant for higher tolerance to these compounds, to facilitate the production of biofuels and biochemicals, and further biocatalytic conversions. In comparison with the parental strain, the regulatory mutant with the upregulated efflux pump AcrAB-TolC produced moderately better growth and higher tolerance to concentrations of furfural and HMF between 1 and 2 g L−1.
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Funding Info:
This work was funded by A*STAR in Singapore ICES/12-574A01.
Description:
This is the peer reviewed version of the following article: Lin, L. H. A.; Lim, C. Y.; Gerken, H.; Wu, J. C.; Zhao, H., Furfural and hydroxymethylfurfural tolerance in Escherichia coli ΔacrR regulatory mutants. Biotechnology and Applied Biochemistry 2015, 62 (1), 32-36, which has been published in final form at https://dx.doi.org/10.1002/bab.1232. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.