High-density impedance-sensing array on complementary metal-oxide-semiconductor circuitry assisted by negative dielectrophoresis for single-cell-resolution measurement
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High-density impedance-sensing array on complementary metal-oxide-semiconductor circuitry assisted by negative dielectrophoresis for single-cell-resolution measurement
High-density impedance-sensing array on complementary metal-oxide-semiconductor circuitry assisted by negative dielectrophoresis for single-cell-resolution measurement
Jaehoon Chung, Yu Chen, Seong-Jin Kim, High-density impedance-sensing array on complementary metal-oxide-semiconductor circuitry assisted by negative dielectrophoresis for single-cell-resolution measurement, Sensors and Actuators B: Chemical, Volume 266, 2018, Pages 106-114, ISSN 0925-4005, https://doi.org/10.1016/j.snb.2018.03.113.
Abstract:
A microarray biosensor that measures the electrical impedance of cell suspensions is presented. Single-cell–resolution measurement was facilitated by physically positioning individual cells on sensing electrodes by dielectrophoresis, obviating chemical or biological surface modification. The high-density(104 × 104) electrode array was incorporated with a complementary metal-oxide-semiconductor (CMOS)integrated chip (IC) to support impedance spectroscopy at frequencies ranging from 100 kHz to 1 MHz, achieving a rapid and cost-effective platform with a small form factor. Experiments with microbeads (10, 15, and 20 m in diameter) and a live breast cancer cell line (MCF-7) have demonstrated that thedeveloped prototype quantifies loaded microbeads or cells rapidly (