Fatehullah, A., Tan, S. & Barker, N. Organoids as an in vitro model of human development and disease. Nat Cell Biol 18, 246–254 (2016).
Abstract:
The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.
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Funding Info:
This work was supported by Agency for Science, Technology and Research (A*STAR). Core Funding