Magkos F, Sullivan S, Fitch M, et al. Effect of Weight Gain and Weight Loss on In Vivo Colonocyte Proliferation Rate in People with Obesity. Obesity (Silver Spring). 2017;25 Suppl 2(Suppl 2):S81‐S86. doi:10.1002/oby.21983
Abstract:
Objective: To evaluate the effects of diet-induced changes in energy balance and body weight on in vivo colonocyte fractional proliferation rates (FPR) in people with obesity.
Methods: In vivo colonocyte FPR was assessed in 31 men and women with obesity (BMI: 35.4 ± 4.0 kg/m2 , age: 52.6 ± 8.9 years) before and after diet-induced weight loss, weight gain, or weight maintenance. Subjects ingested aliquots of 2 H2 O (heavy water) daily for 4 to 7 days, followed by flexible sigmoidoscopy with colon biopsies to assess the incorporation of 2 H into the DNA of dividing colonocytes.
Results: Colonocyte FPR averaged 12.7% ± 3.8% per day and correlated directly with intra-abdominal adipose tissue (IAAT) volume (r = 0.364, P = 0.044). Colonocyte FPR decreased in the weight loss group, did not change in the weight maintenance group, and increased in the weight gain group. The change in colonocyte FPR correlated directly with the percent change in body weight (r = 0.409, P = 0.028) and IAAT volume (r = 0.598, P = 0.001).
Conclusions: A high-calorie diet and weight gain increase, whereas a low-calorie diet and weight loss decrease, in vivo colonocyte proliferation rate in people with obesity. These results suggest that changes in energy balance influence the risk of developing colon cancer in people with obesity by regulating colonic mucosal growth rates.
License type:
PublisherCopyrights
Funding Info:
This study was supported by grants DK 101578, DK 94483, DK 56341 (Nutrition Obesity Research
Center), DK 20579 (Diabetes Research Center), DK052574 (Digestive Disease Research Center), U54 CA155496 (Transdisciplinary Research on Energetics and Cancer Center) and UL1 RR024992 (Clinical and Translational Science Award) from the National Institutes of Health, a grant from the Pershing Square Foundation and grants N7337 (Dr. Robert C. and Veronica Atkins Foundation) and 19-900 (UC Berkeley College of Natural Resources).
Description:
The full paper is available for download at the publisher's URL: https://doi.org/10.1002/oby.21983