Babu, D., Fullwood, M. Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer. Nat Genet 49, 1294–1295 (2017). https://doi.org/10.1038/ng.3944
Abstract:
ERG overexpression in prostate cancers promotes the development of widespread changes in gene expression and chromatin landscapes, leading to redistribution of key transcription factors in prostate cancers positive for the TMPRSS2-ERG fusion gene. The overexpression of ERG is further assisted by the development of a super-enhancer in the ERG locus.
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Funding Info:
This work is carried out as a commentary article. No specific research funding code.