Bard F, Chia J (2017) Comment on “The GalNAc-T Activation Pathway (GALA) is not a general mechanism for regulating mucin-type O-glycosylation”. PLoS ONE 12(7): e0180005. https://doi.org/10.1371/journal.pone.0180005
Abstract:
In the PLOS ONE article “The GalNAc-T Activation Pathway (GALA) is not a general mechanism for regulating mucin-type O-glycosylation”, Tabak and colleagues argue that they cannot
reproduce part of the results we published in 2010 [1]. Specifically, the fact that EGF and
PDGF growth factors stimulation of HeLa cells results in a relocation of the O-glycosylation
initiation enzymes polypeptide N-acetylgalactosaminyltransferase (GALNTs) from the Golgi
apparatus to the endoplasmic reticulum (ER).
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Funding Info:
The funders had no role in study design, data collection and analysis, decision to publish, or
preparation of the manuscript. This is a commentary; not a research publication.