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17 Jul 2020
BMRC
Institute of Molecular and Cell Biology
Global translation during early development depends on the essential transcription factor PRDM10
Brenda Y. Han,
Michelle K.Y. Seah,
Imogen R. Brooks,
Delia H.P. Quek,
Dominic R. Huxley,
Chuan-Sheng Foo,
Li Ting Lee,
Heike Wollmann,
Huili Guo,
Daniel M. Messerschmidt,
Ernesto Guccione
Nature Communications
10 Jan 2020
BMRC
Institute of Molecular and Cell Biology
PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly
Slim Mzoughi,
Federico Di Tullio,
Diana H. P. Low,
Corina-Mihaela Motofeanu,
Sheena L. M. Ong,
Heike Wollmann,
Cheng Mun Wun,
Paul Kruszka,
Maximilian Muenke,
Friedhelm Hildebrandt,
N. Ray Dunn,
Daniel M. Messerschmidt,
Ernesto Guccione
Science Advances
17 Dec 2019
BMRC
Institute of Molecular and Cell Biology
Discovery of a chemical probe for PRDM9
Abdellah Allali-Hassani,
Magdalena M. Szewczyk,
Danton Ivanochko,
Shawna L. Organ,
Jabez Bok,
Jessica Sook Yuin Ho,
Florence P. H. Gay,
Fengling Li,
Levi Blazer,
Mohammad S. Eram,
Levon Halabelian,
David Dilworth,
Genna M. Luciani,
Evelyne Lima-Fernandes,
Qin Wu,
Peter Loppnau,
Nathan Palmer,
S. Zakiah A. Talib,
Peter J. Brown,
Matthieu Schapira,
Philipp Kaldis,
Ronan C. O’Hagan,
Ernesto Guccione,
Dalia Barsyte-Lovejoy,
Cheryl H. Arrowsmith,
John M. Sanders,
Solomon D. Kattar,
D. Jonathan Bennett,
Benjamin Nicholson,
Masoud Vedadi
Nature Communications
16 Sep 2019
BMRC
Institute of Molecular and Cell Biology
The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex
Suneesh Kaimala,
Jimsheena V. Karakkat,
Sreejisha P. Sreedharan,
Princy Jayaprakash,
Ernest A. Adeghate,
Suraiya A. Ansari,
Ernesto Guccione,
Eric P. K. Mensah-Brown,
Bright Starling Emerald
Nucleic Acids Research
26 Jul 2019
BMRC
Institute of Molecular and Cell Biology
CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I
Philipp Kaldis,
Nathan Palmer,
S. Zakiah A. Talib,
Chandrahas Koumar Ratnacaram,
Diana Low,
Xavier Bisteau,
Joanna Hui Si Lee,
Elisabeth Pfeiffenberger,
Heike Wollmann,
Joel Heng Loong Tan,
Sheena Wee,
Radoslaw Sobota,
Jayantha Gunaratne,
Daniel M. Messerschmidt,
Ernesto Guccione
Journal of Cell Biology
10 Jul 2019
BMRC
Institute of Molecular and Cell Biology
The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.
Michelle K. Y. Seah,
Yaju Wang,
Pierre-Alexis Goy,
Hui Mun Loh,
Wen Jun Peh,
Diana H. P. Low,
Brenda Y. Han,
Esther Wong,
Ei Leen Leong,
Gernot Wolf,
Slim Mzoughi,
Heike Wollmann,
Todd S. Macfarlan,
Ernesto Guccione,
Daniel M. Messerschmidt
Development
1 May 2019
BMRC
Institute of Molecular and Cell Biology
Epigenetic Regulation of the PTEN–AKT–RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma
(Pending publish)
Akshay V. Bhat,
Monica Palanichamy Kala,
Vinay Kumar Rao,
Luca Pignata,
Huey Jin Lim,
Sudha Suriyamurthy,
Kenneth T. Chang,
Victor K. Lee,
Ernesto Guccione,
Reshma Taneja
2 Apr 2019
BMRC
Institute of Molecular and Cell Biology
Proteomics profiling of arginine methylation defines PRMT5 substrate specificity
Daniele Musiani,
Jabez Bok,
Enrico Massignani,
Liling Wu,
Tommaso Tabaglio,
Marica Rosaria Ippolito,
Alessandro Cuomo,
Umut Ozbek,
Habiba Zorgati,
Umesh Ghoshdastider,
Robert C. Robinson,
Ernesto Guccione,
Tiziana Bonaldi
Science Signaling
7 Sep 2018
BMRC
Institute of Molecular and Cell Biology
MBNL1 alternative splicing isoforms play opposing roles in cancer
Tommaso Tabaglio,
Diana HP Low,
Winnie Koon Lay Teo,
Pierre Alexis Goy,
Piotr Cywoniuk,
Heike Wollmann,
Jessica Ho,
Damien Tan,
Joey Aw,
Andrea Pavesi,
Krzysztof Sobczak,
Dave Keng Boon Wee,
Ernesto Guccione
Life Science Alliance
19 Jul 2018
BMRC
Institute of Molecular and Cell Biology
PRMT5-mediated regulation of developmental myelination
Patrizia Casaccia,
Antonella Scaglione,
Julia Patzig,
Jialiang Liang,
Rebecca Frawley,
Jabez Bok,
Angeliki Mela,
Camila Yattah,
Jingxian Zhang,
Shun Xie Teo,
Ting Zhou,
Shuibing Chen,
Emily Bernstein,
Peter Canoll,
Ernesto Guccione
Nature Communications
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