Jackson, A. W., Octreotide end-functionalized diblock copolymers facilitated by RAFT polymerization. Journal of Polymer Research 2017, 24 (4) : Article 64, DOI: 10.1007/s10965-017-1220-9.
Abstract:
The incorporation of biologically active targeting ligands into polymeric materials is a key challenge in drug delivery and bioimaging. Reported here is the synthesis of diblock copolymers end-functionalized with the Somatostatin analog Octreotide. This methodology employs a novel Octreotide functional reversible addition-fragmentation chain transfer (RAFT) polymerization chain transfer agent, which is used to mediate the polymerization of N-isopropylacrylamide and subsequent chain-extension with N,N-dimethylacrylamide.
License type:
PublisherCopyrights
Funding Info:
This research was supported by the JCO Grant (1131CFG002) of A* Star (Agency for Science Technology and
Research).
Description:
This is a post-peer-review, pre-copyedit version of an article published in Journal of Polymer Research. The final authenticated version is available online at: https://doi.org/10.1007/s10965-017-1220-9