Winanto, Khong ZJ, Hor JH, Ng SY. Spinal cord organoids add an extra dimension to traditional motor neuron cultures. Neural Regen Res [serial online] 2019 [cited 2020 Apr 30];14:1515-6. Available from: http://www.nrronline.org/text.asp?2019/14/9/1515/255966
Abstract:
Since Lancaster et al. (2013) first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human. The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones, making it a great tool to study neurodevelopment and neurodegeneration. Neural
organoids are 3D cell culture systems formed by proliferating, differentiating, migrating and self-organizing pools of neural progenitors. They mimic brain structures in their cell type composition, cytoarchitecture, and to some extent maturity and functionality (Lancaster et al., 2013).